The driver of a car was also killed when a medical transport plane crashed in Philadelphia, the city’s mayor has confirmed.
All six on board were killed in the crash – a young patient and her mother, on their way home to Tijuana, Mexico, along with four crew members.
At least 19 others were also injured in the crash, which left several homes engulfed in flames.
The child on board had just completed treatment for a life-threatening condition and the plane crashed around 30 seconds after taking off.
In a news conference on Saturday, mayor Cherelle Parker confirmed another person had died, who was in a car when the plane crashed.
She added the number of injured may rise.
Adam Thiel, managing director for the city of Philadelphia, said it would likely be days until the total number of dead and injured was known.
Black Hawk helicopter was on ‘doomsday’ practice mission before Washington DC crash with passenger plane, officials say
Donald Trump hits Canada, Mexico and China with tariffs – amid fears US consumers could suffer
How Donald Trump’s tariffs could impact consumers
He added authorities were still trying to get a sense of how large the incident was, and how far debris was scattered.
Teams were now going house to house to inspect dwellings in the area for damage.
Jet Rescue Air Ambulance, which operated the Learjet 55, previously said in a statement: “We cannot confirm any survivors.”
The plane came down near the Roosevelt Mall in the Rhawnhurst area of Pennsylvania at 6.30pm local time on Friday (11.30pm UK time).
On Saturday, in a statement on social media Mexican President Claudia Sheinbaum confirmed the six initially confirmed deaths were all Mexican nationals.
The child had received care at Shriners Children’s hospital and was heading to Missouri before flying onward to Mexico.
Follow our channel and never miss an update
It comes after 67 people were said to have died after an American Airlines passenger jet and a military helicopter collided mid-air, in Washington DC.
This breaking news story is being updated and more details will be published shortly.
Please refresh the page for the fullest version.
You can receive breaking news alerts on a smartphone or tablet via the Sky News app. You can also follow us on WhatsApp and subscribe to our YouTube channel to keep up with the latest news.